KEYBOARD CONTROLS: Z / X / A / S / Q/ E / Arrows: left right up down
In Dr. Mario, the objective is to eliminate all the viruses contained in a big bottle. Dr. Mario (situated in the upper-right side of the screen) will throw capsules with 6 different color combinations (Red-Red, Red-Blue, Yellow-Yellow, Red-Yellow, Blue-Blue and Blue-Yellow) in order to line up at least four viruses or capsules of the same color horizontally or vertically and to make them disappear.